Explainer Animation Videos never been that cheap

Have you ever saw one of those explainer video on a website, trying to explain how to use a website or the concept of the startup or website ?
Do you have an idea how much it cost to have such a video created? 1000$, yes a thousand dollar the cheapest one! Crazy !
Well I stumbled upon a nice company that have very nice videos done, and what is interesting is that they are cheap, really cheap , you can get a video explainer for 50$! And the quality is good!
The 50$ videos I’ve seen are better than videos that were made by some other companies for 1000$.
You can have a look at some of the videos done on this website:
Animation videos

Potentially game changing data awaits Acorda in 2013

Patrick Sarmiere, a scientist, is seen at an Acorda lab in Ardsley, New York in this 2010 Acorda Therapeutics, Inc. handout picture. Acorda Therapeutics Inc Chief Executive Ron Cohen is already looking to spring, when data on a new use for its lone product could spur renewed investor interest and provide funding to enable his company to develop even more therapies. REUTERS/Ben Chrisman/Acorda Therapeutics, Inc./Handout

NEW YORK | Thu Dec 20, 2012 9:58am EST

(Reuters) – Acorda Therapeutics Inc Chief Executive Ron Cohen is already looking to spring, when data on a new use for its lone product could spur renewed investor interest and provide funding to enable his company to develop even more therapies.

The 2010 approval of Ampyra to improve walking in multiple sclerosis patients turned Acorda into a profitable company last year. If the drug can also help stroke victims who have suffered long term disability, it would open a large new market for Ampyra.

“If it works (in stroke) it’s a game changer for us,” Cohen told Reuters in the course of two recent conversations.

About half of the seven million people who have had a stroke have enough disability to make them potentially eligible for Ampyra treatment, Cohen said.

Ampyra, a drug that enhances signal transmission in damaged nerves, is expected to have sales in excess of $300 million next year, but company shares are down nearly 30 percent since the drug was launched in March of 2010.

An approval for stroke “could potentially double the company’s sales,” said RBC Capital Markets analyst Michael Yee.

“That is worth betting on given the significant upside,” Yee said. “The stock is underappreciating just sales in MS, let alone another indication that could double the company’s sales.”

Data from the eagerly awaited midstage post stroke study is due out in the second quarter of 2013.

“Right now, we can say with confidence that people who have pet rats that have suffered stroke we can help,” Cohen said with a chuckle.

The Phase II trial involves 66 people who suffered a stroke at least six months prior. “So it’s chronic disabilities. We’re measuring walking behavior as well as upper extremity disability,” Cohen said.

Ampyra is also being tested in a 20-patient trial of adults with cerebral palsy. That data is expected by the middle of 2013, giving the company yet another shot on goal for its lone product. “It’s one of those things you look at and go ‘it should work’,” Cohen said.

PIPELINE IN A PRODUCT

“The current pipeline is going to take a few years to mature even if it all works. One of the options is to have Ampyra in essence be a pipeline in a product,” Cohen explained. “So if we can show that it applies elsewhere, that’s going to help grow the company and enable us to do a lot more things.”

Acorda, which has more than $300 million in cash, is also looking to add products through deals.

“Would we pay $100 million for an opportunity? Sure, if we thought it was going to be a big enough opportunity. We’re looking for things that we think could get to market within the next couple of years,” said the 56-year-old Cohen, a former practicing doctor who once “had pretensions to be an actor” – something he pursued for a few years in New York.

“You couldn’t ask for a better training ground for what I do now, which is going out and raising money from investors. It’s basically auditioning constantly and always being rejected,” Cohen joked.

He said he began working on Acorda as a startup in late 1993. The company was incorporated in 1995. “I had no idea how drugs were developed. I knew how to administer them.

“It was amazing to me that it required this kind of money and effort,” said Cohen, adding that Acorda raised $600 million to develop Ampyra. “We did it on the cheap.”

Ardsley, New York-based Acorda will decide by the end of this year whether to exercise its option to buy Neuronex Inc and its nasal spray version of diazepam – the chemical name for Valium – to treat epileptic seizures. Acorda paid $2 million up front for the option and will have to pay only another $6.8 million to complete the acquisition.

By the end of next year, Cohen said, Acorda is likely to have three novel products move into clinical trials, including a molecule called GGF2, a nerve growth factor that holds promise for treating several debilitating conditions.

The first use to be tested will be for heart failure for which there are few good treatment options. It appears to work by “normalizing the metabolism of the damaged cells, so you actually get a more normal functioning heart muscle as opposed to something that reduces blood pressure so the heart is not taxed as much. So that’s really exciting,” Cohen explained.

GGF2 also has potential to help preserve or restore function even days after patients have suffered acute stroke, as well as address spinal cord injuries and restore erectile function following prostate surgery, Cohen said.

“The problem for us is we only have one drug generating revenue, so there’s only so much we can invest in at one time.”

But Cohen is anxious to see GGF2 tested on men for its potential to repair the cavernous nerve often damaged during delicate prostate surgery. About half the estimated 250,000 men who have prostate surgery each year suffer erectile dysfunction.

Researchers at Johns Hopkins have tested the theory on rats.

“The Hopkins group showed that if you apply this around the time of the injury the nerve grows back and you keep the erectile function,” Cohen said. “So there are a lot of happy rats in Baltimore.”

(Reporting by Bill Berkrot; Editing by Jilian Mincer and Tim Dobbyn)

Amanda Doherty Pete Travis

Study: Kids Should Drink Exactly Two Cups of Milk Per Day

Got (just the right amount, not too much, but not too little) milk?

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Reuters

PROBLEM: Still in the throes of “Got Milk?” inundation, disagreement is rife over whether drinking cow’s milk is as good for us as we’ve been led to believe. After all, critics argue, it’s estimated that up to 75 percent of people experience a reduction in their ability to digest milk after infancy, and the beverage has also been associated with iron deficiency — not only because it’s low in iron itself, but because it also hinders the body’s ability to absorb iron from other sources. Milk remains, on the other hand, an important source of vitamin D, which among other things, has been shown to protect against both diabetes and the common cold in children. So, should you be giving your kids milk? And if so, how much?


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METHODOLOGY: Canadian researchers tracked the milk drinking habits of 1,300 “healthy urban preschoolers” over the course of two years. The children also submitted blood samples (probably reluctantly) from which their iron and vitamin D levels could be analyzed. Skin pigmentation, whether or not they were breast fed, use of vitamin D supplements, and variations in season (which affects how much sunlight they get) were all taken into account.

RESULTS: As children consumed more cow’s milk, their blood levels of vitamin D increased, but their iron levels proportionately decreased. At two glasses per day, however, children were able to get a healthy level amount of vitamin D without losing too much iron.

CONCLUSION: While there is a trade-off between the health benefits — increased vitamin D — and negative effects — depleted iron — of drinking milk, two cups a day seems to strike the ideal balance for young children.

IMPLICATIONS: Vitamin D is important, but milk is only a good source of it in moderation. During the winter months, and especially for children with darker skin pigmentation, the researchers suggest that children be given vitamin D supplements rather than extra milk.

The full study, “The Relationship Between Cow’s Milk and Stores of Vitamin D and Iron in Early Childhood,” is published in the journal Pediatrics.

This article available online at:

http://www.theatlantic.com/health/archive/2012/12/study-kids-should-drink-exactly-two-cups-of-milk-per-day/266437/

Anne Heche Lavinia Milosovici

The Case Against a Smoke-Free America

There is such thing as a refined taste for tobacco, and enjoying it in moderation.

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Claudia Daut/Reuters

If a time traveler from the early 1990s were to arrive in the U.S. bars and restaurants of today, what would notice first? Perhaps that the food has become more interesting and varied, or that a perplexing number of diners are photographing it with their remarkable phones. The most obvious change, however, might register on the nose: the nearly complete absence of indoor smoking.

California implemented the United States’ first modern statewide smoking ban in 1998. Today twenty-nine states and 703 municipalities require bars and restaurants to be smoke-free, according to data maintained by the Americans for Nonsmokers’ Rights Foundation (North Dakota brought the tally to thirty states this month). Tobacco use has been banished from our culinary radar along with the question “smoking or non?” Most of us don’t miss it. Yet as a slew of new bans, taxes, and regulations drive smoking to the peripheries of society, it’s worth giving tobacco another look.

Tobacco is viewed as pure vice by public health officials. Surgeon General Everett C. Koop famously hoped for a smoke-free America by the year 2000. Koop echoed Lucy Page Gaston, the early twentieth century prohibitionist who campaigned for “a smokeless America by 1925.” This impulse was revived by Surgeon General Richard Carmona, who testified before Congress in 2003, “I see no need for any tobacco products in society.”

But millions of people do see the need, and they’re not all just looking for a nicotine hit. There is much more to tobacco than mass-produced cigarettes; premium tobacco is arguably every bit as artisanal as many of the other food and drink products that those of us in the culinary world obsess over. The unique leaf offers flavors that many find enticing, appearing occasionally in the works of creative chefs, bartenders, and baristas. At the French Laundry, Thomas Keller experimented successfully with desserts like coffee custard infused with tobacco. In Tampa, Cigar City Brewing crafts beers inspired by cigars. Tobacco bitters appear on fancy cocktail menus. In France, distiller Ted Breaux makes a liqueur called Perique that captures the essence of Louisiana pipe tobacco; it’s a remarkable elixir with a light, tea-like quality, and alas, as of this writing not imported to the United States. (Cautionary note: Tobacco infusions can extract dangerous levels of nicotine, so anyone curious to attempt one should first do careful research.)

Links between alcohol and tobacco are not new. In Elizabethan England, the then novel act of smoking was described as “dry drinking.” The metaphor is apt: Neither alcohol nor tobacco is essential to life, but both offer pleasant flavors while enhancing mood and sociality. And, of course, both are harmful when consumed in excess.

RTR24PL6inset.jpgStefan Wermuth/Reuters

My own introduction to tobacco came through the drink world too, though with coffee instead of alcohol. In my days as a barista, one of my best customers was a fitness instructor and avid cigar smoker. This combination perplexed me until I realized that he talked about his cigars the same way I talked about coffee. The varietal of the plant and the origin of the leaf mattered, a Cameroon wrapper tasting differently than one from Nicaragua. Flavors ranged from light claro tobacco to deep, dark oscuro, much as coffee roasts have their own spectrum from light to dark. I eventually realized that cigars offered rewards similar to those of the food and drink with which I was already enamored.

Though access to other quality goods has expanded in recent years, tobacco is ever more restricted. Smoking bans make it difficult to enjoy. Taxes make it expensive. And the Food and Drug Administration, which may soon regulate cigars, threatens to stifle the industry with heavy-handed rules.

Smoking bans are the most obvious difficulty for those of us who enjoy cigars. A good cigar could take an hour or more to burn, so huddling in the cold and rain to have one isn’t an appealing option. Smoking bans are an inconvenience to all smokers, but for cigar smokers they can mean not lighting up at all.

Not content with banning smoking in most indoor environments, legislators have moved on to shutting down the remaining exceptions and extending bans outdoors and into private homes. The bans creep steadily forward, beginning with seemingly reasonable exemptions that are soon eroded. Boston, Massachusetts is a prime example. The city’s original ban grandfathered in six existing cigar bars. This was apparently six too many for the city of more than 600,000 people, so a later ban wiped out that allowance and extended to outdoor patios. Boston’s remaining cigar bars are slated to shutter after a grace period, a delay granted because, as one member of the Boston Public Health Commission so generously put it, “We wanted to give them a bit more time to get used to the idea that they’ll have to close.”

Boston is far from alone. New York is banning smoking in parks. California has banned it on many beaches. In much of sunny Los Angeles one can no longer smoke on restaurant patios. The entire town of Calabasas, California, is smoke-free in public places. San Francisco suburb San Rafael has banned smoking in all multi-unit residences. In Oregon it’s essentially illegal to open a new cigar bar or smoking lounge. In North Dakota voters recently approved a ban that includes tobacco shops. In rainy Washington, even an indoor private smoking club protected by a twenty-five foot airlocked walkway was deemed to be in violation of the statewide ban. I could go on. Non-smokers understandably prefer to avoid secondhand smoke, but really, where’s a smoker supposed to go?

Taxes are another threat. As the percentage of smokers has fallen, tobacco has become an easy target for taxation. Tobacco taxes present an attractive opportunity to raise revenue while discouraging an unpopular activity.

The argument for tobacco taxes appears solid at first glance: Smokers impose health costs on the government, so it’s fair to make them pay for it. However the fiscal argument is not as clear as it seems. To put it bluntly, heavy smokers pay a lot of taxes and then die early. That’s nothing to cheer, but it does reduce governments’ health and retirement costs. Numerous studies, including a commentary from the Congressional Budget Office published last month in the New England Journal of Medicine, confirm that in the long-run smokers are generally self-financing.

Cigars and pipe tobacco have faced less tax pressure than cigarettes, but that is changing. The 2009 Children’s Health Insurance Program Reauthorization Act raised tobacco taxes across the board, including an eight-fold tax increase on large cigars. An unintended consequence of this law has been a shift in consumption. Pipe tobacco, which is taxed at a lower rate than cigarettes and roll-your-own tobacco, boomed in popularity as smokers began buying it to make their own cigarettes. Similarly, producers of small cigars added weight to their products to qualify as lesser taxed large cigars. The result is that an unusual coalition that includes public health groups, cigarette producers, and government agencies has come together to call for fixing the disparity.

Higher taxes would be detrimental to local smoke shops, among the few refuges left to cigar smokers. Some customers are simply priced out of the market, while others turn to online sales. And floor taxes, which are applied all at once to a store’s existing stock, can trigger such a substantial one-time cost that they shut down stores entirely.

RTR207XTinset.jpgRegis Duvignau/Reuters

Finally, there looms the threat of the Food and Drug Administration, which is signaling its intent to begin regulating premium tobacco. Anyone who liked clove cigarettes, which have been banned along with all flavorings aside from menthol, has already felt the pinch of new regulations. A 2011 report from the FDA suggests also banning menthol cigarettes, despite finding insufficient evidence that they are inherently more dangerous than their unflavored counterparts.

Producers of premium tobacco are understandably skittish about what such a mindset may mean for their industry. I spoke with Jeff Borysiewicz, Board Chairman of Cigar Rights of America and President of the Corona Cigar Company, about what he worries FDA regulation may entail. While this is inherently speculative, among the possibilities he cited are restrictions that would eliminate online sales or walk-in humidors, forced display of graphic warning labels on packaging, new fees and taxes, bans on promotional giveaways and events, regulation of nicotine content, and a requirement that new blends be approved by the agency prior to sale. Prior approval could be time-consuming, expensive, and may block some blends from ever coming to market. There is also the possibility that flavored cigars — not just “candy” flavors but also adult flavors like rum and cognac — could be forbidden, a measure pushed by several United States senators and already enacted in New York City.

Such regulations would drastically impact the cigar industry. In response, cigar advocates have introduced legislation to exempt premium cigars from FDA regulation. H.R. 1639, the “Traditional Cigar Manufacturing and Small Business Jobs Preservation Act,” would create a new definition for large cigars, requiring them to weigh at least six pounds per thousand count, contain no filter, and be wrapped in tobacco leaf. This definition is designed to distinguish traditional premium cigars from the “drugstore cigars” that have boomed in popularity thanks to tax and regulatory changes. Given the uncertainty of FDA regulation and the potential hostility the agency may hold toward the industry, this would be a sensible step.

More generally, we must stop treating smoking as pure vice. Lost in discussions of the very real problem of how to reduce deaths from smoking is an acknowledgement that tobacco has redeeming qualities, that it can be enjoyed in moderation, and that not all forms of tobacco use are equally dangerous. We can and should educate consumers about the risks of tobacco and tax it appropriately. But we should also respect the rights of consenting adults to gather in private places and decide for themselves what to ingest into their bodies. That doesn’t necessitate going back to the days of smoking on airplanes, but it does require fighting back against the extreme measures sought by today’s anti-smoking movement. It requires letting smokers have a few rooms of their own and not destroying the tobacco industry with excessive taxes and regulations.


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I know that my own life has been improved by friendships deepened over sessions with cigars, and the match of a good cigar with an equally good rum or whiskey is as compelling as any wine and food pairing I’ve encountered. Having overcome my own anti-smoking prejudice, I’ve learned that it’s an indulgence worth defending.

There’s a funny legend about Sir Walter Raleigh, the Englishman who helped popularize pipe tobacco brought over from the New World. A servant, seeing him exhaling smoke, concluded that Raleigh was on fire and promptly doused him. Today’s anti-smoking activists understand tobacco about as poorly as Raleigh’s servant and have acquired some very large pails of water. Let’s not allow them to extinguish something wonderful.

Ian McKellen Anne Heche

Daylight savings tied to bump in heart attack rates

NEW YORK (Reuters Health) – Setting the clock ahead for daylight savings time may set the scene for a small increase in heart attacks the next day, according to a small new study that suggests sleep-deprivation might be to blame.

Researchers at two Michigan hospitals reviewed six years of records and found that they treated an average of 23 heart attacks on the Sunday Americans switched to daylight savings time. That compared to 13 on a typical Sunday.

“Nowadays, people are looking for how they can reduce their risk of heart disease and other ailments,” said Dr. Monica Jiddou, the study’s lead author and a cardiologist at William Beaumont Hospital in Royal Oak.

“Sleep is something that we can potentially control. There are plenty of studies that show sleep can affect a person’s health,” she added.

But one cardiologist not involved with the new study cautioned that people should be careful interpreting the findings.

“We haven’t generally thought that missing an hour of sleep causes heart attacks. This may or may not hold up,” said Dr. Steven Nissen, chair of the Robert and Suzanne Tomsich Department of Cardiovascular Medicine at the Cleveland Clinic.

This is not the first study, however, to find a connection between semiannual time shifts and heart attack rates.

A 2008 Swedish report, for instance, found the chance of a heart attack increased in the first three weekdays after the switch to daylight savings time, and decreased the Monday after the clocks returned to standard time in the fall. (See Reuters Health article of October 30, 2008. http://reut.rs/Z6cSH2)

Jiddou told Reuters Health that her team, which published its findings in The American Journal of Cardiology, wanted to see if their respective hospitals experienced the same increase and decrease in heart attacks seen in the Swedish study.

For the new work, she and her colleagues reviewed records for the 328 patients who were diagnosed with a heart attack during the week after a time change between 2006 and 2012, and for the 607 heart attack patients who were treated two weeks before and after the time shifts.

They found that except for the small increase on the Sunday that daylight savings time kicked in, there were no significant differences in heart attack rates in the first week after the spring clock change or in the fall, when people set clocks back.

The authors note, however, that the small trends they observed suggest shifts to and from daylight savings time may be linked with small increases in heart attacks in the spring, and small decreases in the fall.

They speculate that sleep-deprivation resulting from the time changes could raise levels of stress hormones and inflammatory chemicals just enough to trigger a heart attack, especially in those already at high risk.

Though the slight increase in heart attacks in the days following time shifts were so small they could have been due to chance, Jiddou told Reuters Health that she believes the problem was the size of the study population.

“(The findings) weren’t significant, but I think a lot of that is just because we didn’t have the numbers,” Jiddou.

“The numbers aren’t necessarily striking, but the trends make you stop and think,” she added.

Nissen told Reuters Health that the study looks at a good question and that he applauds the researchers’ efforts, but stressed the limitations of the results.

“Whenever you do this type of study you worry whether it’s by chance or not,” he said. “The size of the effect is not huge even though I realize the data on the first day seems worse.”

Jiddou said she doesn’t think the average person should be overly concerned, “but I think it’s something that they should be aware of.”

SOURCE: http://bit.ly/W391bW The American Journal of Cardiology, online December 10, 2012.

Hedy Burress Christina Applegate

Parents warned children raiding kitchen cupboards to try and create ‘legal highs’

  • Children as young as nine experimenting with kitchen cupboard essentials such as cinnamon and nutmeg to try and create ‘drug-like effects’
  • Dozens of children treated in emergency rooms after trying to swallow cinnamon, while two choked to death on marshmallows
  • ‘Seemingly silly games can have sinister effects,’ Chicago doctors warn

By Claire Bates

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Parents have been warned to watch their kitchen cupboards, after a spate of hospital admissions of children pursuing ‘legal highs.’

Researchers said youngsters were downing cinnamon, snorting nutmeg and even experimenting with marshmallows to try and create a drug-like effect.

Dr Christina Hantsch, from Loyola University Hospital in Chicago, felt compelled to speak out after a dozen nine-year-olds were treated in emergency departments.

A teenager about to attempt the 'Cinnamon Challenge.' Doctors have warned it could cause choking

A teenage girl about to attempt the ‘Cinnamon Challenge,’ which was posted on Youtube. Doctors have warned it could cause choking

They had been attempting to perform an internet craze known as the ‘Cinnamon Challenge’, which involves trying to swallow one tablespoon of ground cinnamon without water.

‘One girl had seen videos on the Internet and wanted to try it with her friends,’ Dr Hantsch said.

‘The dry, loose cinnamon triggers a violent coughing effect and also a burning sensation that actually can lead to breathing and choking hazards.’

In 2011, poison centres received 51 calls about teen exposure to cinnamon. In just the first three months of 2012, they had received 139 calls.

The American Association of Poison Control Centers reports that of those, 122 were classified as intentional misuse or abuse and 30 callers required medical evaluation.

‘The envelope is always being pushed to create something new that will get attention, potentially create a drug-like effect and can pass under the radar of law enforcers,’ Dr Hantsch said.

Parents have been warned to keep an eye on their kitchen cupboards as children try out dangerous games they find online

Parents have been warned to keep an eye on their kitchen cupboards as children try out dangerous games they find online

She added that she was concerned what was once horseplay by older teenagers is now being copied by younger children.

‘They have easy access to ingredients like cinnamon and marshmallows and think it is cool to do what their older peers are doing,’ Dr Hantsch said.

Another ‘game’ involving marshmallows continues to attract followers.

‘Two children have actually choked to death attempting this game, so it is not to be taken lightly,’ Dr Hantsch said.

Ground nutmeg has been snorted, smoked and eaten in large quantities in an attempt to produce a drug-like high.

Other common household products that are also being abused are hand sanitiser, ink markers and glue.

Dr Hantsch said: ‘Seemingly silly games can have sinister effects and the holidays are the worst time for this to happen.

‘Kids have more free time, greater access to the Internet and more opportunities to get together during vacations. And at Christmas, the kitchen pantry is loaded for holiday baking.

‘Adults are wise to keep an eye on their children to make sure they are using the ingredients for their proper use.’

more stories Drake

Western Illinois hires Nielson as coach

Published: Dec. 19, 2012 at 12:34 PM

MACOMB, Ill., Dec. 19 (UPI) – Bob Nielson, who won two Division II titles and 100 games during the last 10 seasons, has been hired as head football coach at Western Illinois.

Nielson, 53, replaces Mark Hendrickson, who was fired last month as Western Illinois finished the season 3-8 overall and 1-7 in the Missouri Valley Conference.

The Leathernecks were in the NCAA FCS playoffs after the 2010 season but are 5-17 (2-14 conference) since then.

Nielson built a 100-26 record in 10 years at Minnesota-Duluth. His teams won NCAA Division II championships twice, claimed five Northern Son Intercollegiate Conference titles and were 11-0 in the regular season three times.

He previously coached at Wartburg (Iowa), Ripon (Wis.) and Wisconsin-Eau Claire. His record in 20 seasons as a head coach is 170-59-1.

Kim Cooper Nicole Richie

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